Research teams and research areas

The Institut de la Vision brings together nearly 300 researchers in 18 research units specialized in ophthalmological pathologies. At the forefront of scientific innovation, these units conduct translational research aimed at developing cutting-edge technological solutions and therapeutic innovations for the prevention, diagnosis and treatment of these pathologies. Organized around five strategic research axes, the teams of the Institut de la Vision cover a wide range of topics, from the molecular physiology of vision to innovative therapeutic approaches.

Quantitative in vivo corneal and ocular microscopy

The group “Quantitative in vivo corneal and ocular microscopy” led by Kristina Irsch focuses on solving problems inherent to ophthalmic imaging in those suffering from actual pathology.

Kristina Irsch
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Presentation

Axis 1 - Overcoming human-factor limitations inherent to patient imaging: 

Objective 1 - Characterization of anterior-segment transparency with tailored instrumentation; 

Objective 2 - Compensation for anterior-segment transparency imperfections and loss. Emerging efforts also focus on turning some inherent ocular characteristics, such as eye movements or ocular scattering, to potential advantage: 

Axis 2 - Can human-factor limitations be turned to improve ocular imaging? 

Objective 3 - Using light scattering for high-resolution ocular imaging; 

Objective 4 - Using ocular motion as a shifting or scanning mechanism.  To achieve these objectives, the group develops innovative tools using original physics-based concepts, with an overall goal to realize the potential of the cornea and the eye to serve as a quantitative in vivo microscope into ocular as well as systemic diseases.  

An inter-disciplinary approach is employed involving a synergy between physicists/engineers and ophthalmologists, both within the emerging team and at the national and international level.

Research areas

  • Standardized grading of corneal and lenticular opacities

  • Retinal imaging

  • High resolution ocular imaging

  • Full Field OCT

Team members

Kristina Irsch
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Jean-François Girmens
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Byungjae Hwang
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Scientific publications

Below you will find the latest scientific publications in this field: Quantitative in vivo corneal and ocular microscopy.

A new method for in vivo assessment of corneal transparency using spectral-domain OCT

Maëlle Vilbert; Omnia Hamdy; Romain Bocheux; Cristina Georgeon; Vincent Borderie; Pascal Pernot; Kristina Irsch; Karsten Plamann
PLOS ONE 2023-10-05 | Journal article DOI: 10.1371/journal.pone.0291613

Central fixation detection with an open-frame retinal birefringence scanning system: Optics, optomechanics, polarization balancing aspects, computer modeling and simulation

Boris I. Gramatikov; Kristina Irsch; David L. Guyton
Optics & Laser Technology 2023-08 | Journal article DOI: 10.1016/j.optlastec.2023.109388

Distortion matrix concept for deep imaging in optical coherence tomography

Paul Balondrade; Victor Barolle; Amaury Badon; Ulysse Najar; Kristina Irsch; Mathis Fink; Claude Boccara; Alexandre Aubry
2021-10 | Conference paper DOI: 10.1109/IPC48725.2021.9593006

Distortion matrix concept for deep optical imaging in scattering media

Amaury Badon; Victor Barolle; Kristina Irsch; A. Claude Boccara; Mathias Fink; Alexandre Aubry
Science Advances 2020-07-24 | Journal article | DOI: 10.1126/sciadv.aay7170

Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD OCT.

Nature communications 2020-04-20 | Journal article | DOI: 10.1038/s41467-020-15792-x

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