Retinal development and repair

We are working on cell therapy using the implantation of stem cell-derived retinal cells. This constitutes a therapeutic option for the treatment of retinal degenerative diseases, affecting photoreceptors and retinal pigment epithelial cells.

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Presentation

Our team is at the forefront of the development of cell-based therapies to tackle degenerative diseases of the retina, such as hereditary retinal dystrophies and age-related macular degeneration (AMD). We focus on basic and translational research using human induced pluripotent stem (iPS) cells to create 3D retinal avatars, called retinal organoids, by recapitulating human retinogenesis.

The aims of our laboratory are to use these organoid models to gain a better understanding of the cellular and molecular events that occur during human retinal development, and to generate retinal cells and tissues that can be used for modelling retinal diseases and developing different types of cell therapy.

Research areas

Pluripotent stem cells
Organoids
Cell therapy
Disease Modeling

Team members

Scientific publications

Below you will find the latest scientific publications in this field: Retinal development and repair.

From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium

Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot E, Sahel J-A, Monville C and Goureau O.

Proc. Natl. Acad. Sci. USA 2014, 111, 8518-8523

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Generation of storable retinal organoids and retinal pigmented epithelium from adherent human iPS cells in xeno-free and feeder-free conditions

Reichman S, Slembrouck A, Gagliardi G, Chaffiol A, Terray A, Nanteau C, Potey A, Belle M, Rabesandratana O, Duebel J, Orieux G, Nandrot EF, Sahel JA and Goureau O.

Stem Cells 2017 35(5):1176-1188

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Clinically compatible human ESC-derived RPE cells grafted as an epithelium potentiates vision rescue in dystrophic rodent

Ben M'Barek K, Habeler W, Plancheron A, Jarraya M, Regent F, Terray A, Yang Y, Chatrousse L, Masson Y, Sahel JA, Peschanski M, Goureau O. and Monville C.

Sci. Transl. Med. 2017, Dec 20;9(421)

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Characterization and transplantation of CD73-positive photoreceptors isolated from human iPSC-derived retinal organoids

Gagliardi G, Ben M'Barek K, Chaffiol A, Slembrouck-Brec A, Conart JB, Nanteau C, Rabesandratana O, Sahel J-A, Duebel J, Orieux G, Reichman S, and Goureau O.

Stem Cell Rep. 2018, 11(3):665-680

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Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined. Human brain organoids assemble functionally integrated bilateral optic vesicles

Rodrigues A, Slembrouck-Brec A, Nanteau C, Terray A, Tymoshenko Y, Zagar Y, Reichman S, Xi Z, Sahel J-A, Fouquet S, Orieux G, Nandort EF, Byrne LC, Audo I, Roger JE and Goureau O.

npj Regen. Med. 2022, Aug 16;7(1):39

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