Building a Multimodal Atlas of Vertebrate Development
Invited by Filippo del Bene and Alain Chédotal, Merlin Lange PhD (Chan Zuckerberg Biohub, San Francisco, USA) will speak on Friday July 5 at 11am, in the Amphithéâtre Bailliart, 3rd floor of the Hôpital national des 15-20.
Elucidating the developmental processes of organisms requires a comprehensive understanding of cell lineages across spatial, temporal, and molecular dimensions. Advances in imaging and omics technologies allow us to generate technically challenging multidimensional datasets that capture developmental dynamics at unprecedented resolution and across scales (from molecule to organism).
In this talk, I will describe how we integrate light-sheet microscopy with scRNAseq, yielding a time-resolved multimodal atlas of zebrafish development named Zebrahub (zebrahub.org).I will showcase its application in elucidating the differentiation of complex late pluripotent progenitors.
Finally, I will show our recent effort leveraging Multiomic assays and tracking data to perform in silico experiments and gain mechanistic insights into development and differentiation.
About Merlin Lange
Merlin Lange is a Principal Scientist at the Chan Zuckerberg Biohub in San Francisco. He leads a multidisciplinary project to generate a multimodal atlas for Zebrafish development. The goal is to map developmental processes by integrating light-sheet microscopy, omics technologies, and computation. As a graduate student in Dr. Laure Bally-Cuif's lab, he studied the function of genes associated with neurodevelopmental disorders during development. He then received the RIKEN special fellowship and worked in Japan on the development of neural circuits.