Guillaume Le Bourdellès
PhD Student
Research Team
Development and function of the vertebrate visual systemSpecialty areas
Optical developmentScientific biography
Guillaume Le Bourdellès is an optical engineer who specializes in optical microscopy. His current work focuses on the development of "Two-photon microscopy for investigating vision-related neuronal circuits in zebrafish."
Deciphering the brain circuitry by observing and controlling neural activity is essential to fully understand the mechanisms of vision.
The project aims to advance the study of neuronal networks by developing a novel two-photon-based microscope for high-resolution imaging and manipulation of neuronal activity across the entire brain of zebrafish, a small and transparent tropical fish, ideal for optical investigation. The project will utilize advanced techniques like two-photon light-sheet microscopy, patterned illumination, advanced wavefront shaping and non-linear optical approaches together with fast detection of fluorescent signals. The optical system developed will be applied to investigate long range connections in the zebrafish visual system.